Possibilities for Using Halobacterium salinarum in Biomedical Applications Such as the Production of Novel Antimicrobial Agents in Saline-based Processes
Author: Clarenz Cueto
Faculty Supervisor: José R. de la Torre
Department: Biology
Halobacterium salinarum, a halophilic archaeon, has attracted considerable attention due to its remarkable ability to thrive in high-saline environments. Halobacterium salinarum shows potential for biomedical applications, especially in crafting antimicrobial agents suited for processes reliant on saline conditions. Bioactive compounds synthesized by this extremophile exhibit antibacterial, antifungal, and antiviral activities. These compounds offer a promising foundation for the development of novel antimicrobial agents effective in saline-rich environments, where conventional antibiotics may falter. The goal of this study is to determine the possibilities for using Halobacterium salinarum in biomedical applications and identifying its microbial agents in saline-based processes. The researchers hypothesize that Halobacterium salinarum can be effectively utilized in biomedical applications such as wound care and sterilization procedures through culture optimization, genetic engineering, and metabolic pathway analysis. This study is expected to identify the antioxidant and antimicrobial properties of Halobacterium salinarum and will confirm that they can be a source of new bioactive extracts. Purified compounds derived from Halobacterium salinarum cultures are anticipated to exhibit potent antimicrobial activity against a broad spectrum of pathogenic bacteria, fungi, and viruses. The study also underscores Halobacterium salinarum's promise in addressing antimicrobial resistance and advancing biotechnology, indicating its potential impact on future healthcare solutions.